Description

Methyl 3,5-Diacetamido-2,4,6-Triiodobenzoate is a high-purity, iodinated organic compound primarily used as a key intermediate in the synthesis of X-ray contrast media. Its molecular structure, featuring three iodine atoms, is critical for imparting the radiopacity required in diagnostic imaging agents. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors developing non-ionic, low-osmolar contrast agents for enhanced patient safety and diagnostic clarity.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of iopamidol, ioversol, and other non-ionic X-ray contrast media.
• Diagnostic Imaging: Serves as the core structural component that provides radiopacity in contrast agents used in CT scans, angiography, and myelography.
• Research & Development: Used in academic and industrial R&D for developing new generations of iodinated contrast agents with improved safety profiles.
• Fine Chemical Synthesis: Intermediate for creating other complex, iodine-containing molecules for specialized chemical applications.

Basic Information

Product Name	Methyl 3,5-Diacetamido-2,4,6-Triiodobenzoate
CAS No.	1949-46-8
Molecular Formula	C12H11I3N2O4
Molecular Weight	627.94 g/mol
Synonyms	3,5-Diacetamido-2,4,6-triiodobenzoic acid methyl ester; Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, methyl ester; Methyl 3,5-bis(acetylamino)-2,4,6-triiodobenzoate; Iopamidol intermediate; Ioversol intermediate; Contrast agent intermediate; MIBA (Methyl Iodinated Benzoic Acid derivative)
EINECS	217-775-2

Quality Control

Our Methyl 3,5-Diacetamido-2,4,6-Triiodobenzoate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and tendency for oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.