Description

n-Benzyloxycarbonyl-6-Aminohexanoic Acid is a protected amino acid derivative, specifically a Cbz-protected 6-aminohexanoic acid, widely used as a key building block in organic synthesis. Its primary value lies in providing a versatile linker or spacer arm for the controlled synthesis of peptides, peptidomimetics, and other bioactive molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality raw materials for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel peptide-based drugs, prodrugs, and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce a flexible hexanoic acid spacer.
• Bioconjugation & Linker Chemistry: Serves as a versatile linker for coupling drugs to antibodies, proteins, or polymers in antibody-drug conjugate (ADC) and targeted therapy development.
• Biomaterials & Hydrogel Fabrication: Incorporated into polymer backbones to create biodegradable and functional materials for drug delivery systems and tissue engineering scaffolds.
• Proteomics Research: Employed in the design and synthesis of enzyme substrates, inhibitors, and activity-based probes for biochemical studies.
• Combinatorial Chemistry: A valuable scaffold for generating diverse chemical libraries in drug discovery and high-throughput screening programs.

Basic Information

Product Name	n-Benzyloxycarbonyl-6-Aminohexanoic Acid
CAS No.	1947-00-8
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	6-[(Benzyloxy)carbonylamino]hexanoic Acid; Z-6-Ahx-OH; Nα-Cbz-6-Aminohexanoic Acid; N-Carbobenzoxy-6-aminohexanoic Acid; (6-{[(Benzyloxy)carbonyl]amino}hexanoic acid); Cbz-6-Aminohexanoic Acid; N-Z-6-Aminohexanoic Acid; 6-Aminohexanoic acid, N-[(phenylmethoxy)carbonyl]-
EINECS	217-770-9

Quality Control

Our n-Benzyloxycarbonyl-6-Aminohexanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	68 - 72 °C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.