Description

2,5-Bis(Trifluoromethyl)-1,3,4-Oxadiazole is a high-value, fluorinated heterocyclic compound characterized by its unique oxadiazole ring structure substituted with two trifluoromethyl groups. This molecular architecture imparts exceptional chemical stability, lipophilicity, and electron-withdrawing properties, making it a critical advanced intermediate for demanding synthetic applications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its fluorine content is leveraged to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the production of specialty polymers, coatings, and resins designed for high thermal stability, chemical resistance, and low surface energy.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, facilitating challenging chemical transformations in fine chemical synthesis.
• Energetic Materials Research: Investigated as a component in the formulation of advanced, high-density energetic materials due to its nitrogen-oxygen heterocycle and fluorine content.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on incorporating fluorine atoms into complex molecular architectures to study structure-activity relationships.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)-1,3,4-Oxadiazole
CAS No.	1868-48-0
Molecular Formula	C4F6N2O
Molecular Weight	206.05 g/mol
Synonyms	2,5-Bis(trifluoromethyl)-1,3,4-oxadiazole; 1,3,4-Oxadiazole, 2,5-bis(trifluoromethyl)-; 2,5-Bis(trifluoromethyl)-1,3,4-oxadiazole; 2,5-Di(trifluoromethyl)-1,3,4-oxadiazole; BTO; 2,5-Bis(trifluoromethyl)oxadiazole; 2,5-Bis(trifluoromethyl)-1,3,4-oxadiazol; 2,5-Bis(trifluoromethyl)-1,3,4-oxadiazole (BTO)
EINECS	Contact for details

Quality Control

Our 2,5-Bis(Trifluoromethyl)-1,3,4-Oxadiazole is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP requirements for pharmaceutical development, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the potential sensitivity of fluorinated heterocycles, prolonged exposure to high humidity or extreme temperatures should be avoided. Store separately from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.