Description

Bzl-Ile-Oh CAS NO 1859-49-0 is a protected amino acid derivative, specifically N-Benzyloxycarbonyl-L-isoleucine, widely utilized as a crucial building block in peptide synthesis. Its primary value lies in providing a stable, orthogonal protecting group for the amine functionality, enabling the controlled construction of complex peptide sequences. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential addition of isoleucine residues in automated and manual peptide synthesis protocols.
• Solution-Phase Peptide Chemistry: Used in classical solution-phase methods for constructing peptide fragments and small cyclic peptides.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Employed in the chemical modification of proteins and other biomolecules to introduce specific functional groups or labels.
• Combinatorial Chemistry: A valuable building block for generating diverse peptide libraries for drug discovery and screening applications.
• Biochemical Research: Used in academic and industrial laboratories to study protein structure-function relationships and enzyme-substrate interactions.

Basic Information

Product Name	Bzl-Ile-Oh
CAS No.	1859-49-0
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	N-Carbobenzoxy-L-isoleucine; Z-Ile-OH; Nα-Cbz-L-isoleucine; (2S,3S)-2-[[(Benzyloxy)carbonyl]amino]-3-methylpentanoic acid; N-Benzyloxycarbonyl-L-isoleucine; L-Isoleucine, N-[(phenylmethoxy)carbonyl]-; CBZ-L-Isoleucine; Nα-Z-L-Isoleucine
EINECS	217-463-5

Quality Control

Every batch of Bzl-Ile-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) for all shipments, detailing key parameters such as assay, enantiomeric purity, and impurity profiles. Our quality standards are designed to meet the rigorous demands of GMP-guided production for pharmaceutical intermediates and research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Specific Rotation	-15.0° to -18.0° (c=1 in AcOH)
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.