Description

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride is a high-value fluorinated heterocyclic building block and salt. This compound is critical for introducing the tetrafluoropyrrolidine moiety, a privileged scaffold known to enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily sought after by pharmaceutical and agrochemical research organizations for the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorinated pyrrolidine structure can improve efficacy and environmental profile.
• Fluorinated Building Block: Serves as a versatile precursor for introducing conformational restraint and fluorine atoms into complex organic molecules during process chemistry and scale-up.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for asymmetric catalysis or as a component in organocatalysts.
• Material Science Research: Investigated for incorporation into specialty polymers or advanced materials where fluorination alters surface properties and stability.
• Bioconjugation and Probe Chemistry: Utilized in the design of chemical probes and bioconjugation reagents for biochemical and diagnostic applications.

Basic Information

Product Name	3,3,4,4-Tetrafluoropyrrolidine Hydrochloride
CAS No.	1841-00-5
Molecular Formula	C4H6ClF4N
Molecular Weight	179.54 g/mol
Synonyms	3,3,4,4-Tetrafluoropyrrolidine HCl; Tetrafluoropyrrolidine Hydrochloride; Pyrrolidine, 3,3,4,4-tetrafluoro-, hydrochloride; 1H-Pyrrolidine, 3,3,4,4-tetrafluoro-, hydrochloride; 3,3,4,4-Tetrafluoro-1-pyrrolidine hydrochloride; 3,3,4,4-Tetrafluoropyrrolidinium chloride
EINECS	Contact for details

Quality Control

Our 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, including HPLC purity, NMR confirmation, and residual solvent analysis. Our quality commitment supports cGMP and ISO standards for reliable integration into regulated research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.