Description

Tos-Arg-Ome Hcl CAS NO 1784-03-8 is a protected arginine derivative, specifically the methyl ester of Nα-tosyl-L-arginine hydrochloride. This compound serves as a crucial building block in peptide synthesis, particularly for introducing the arginine residue while protecting the guanidino group from side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the sequential assembly of peptide chains containing arginine.
• Solution-Phase Peptide Synthesis: Used in classical coupling methodologies for producing custom peptides and peptide conjugates.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in the study of enzyme-substrate interactions, particularly for proteases like trypsin, where arginine is a recognition site.
• Production of Peptide Mimetics: Used to synthesize arginine analogs and modified peptides for drug discovery and development.
• Reference Standard: Acts as a high-purity standard for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	Tos-Arg-Ome Hcl
CAS No.	1784-03-8
Molecular Formula	C14H23ClN4O4S
Molecular Weight	378.87 g/mol
Synonyms	Nα-Tosyl-L-arginine methyl ester hydrochloride; L-Arginine, N2-[ (4-methylphenyl)sulfonyl]-, methyl ester, hydrochloride (1:1); Methyl Nα-tosyl-L-argininate hydrochloride; TOS-ARG-OME HCL; Tosyl-L-arginine methyl ester hydrochloride; TAME hydrochloride; Nα-Tos-Arg-OMe·HCl
EINECS	Contact for details

Quality Control

Our Tos-Arg-Ome Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	+15° to +20° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.