Description

2',3',5',6'-Tetrafluoroacetanilide is a specialized fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique tetrafluoro substitution pattern on the aniline ring makes it a valuable building block for introducing specific fluorine motifs into target molecules, which can dramatically alter their physical, chemical, and biological properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where fluorine atoms enhance bioavailability, metabolic stability, and target specificity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of fluorinated polymers, liquid crystals, and advanced organic electronic materials.
• Fluorine Chemistry & Catalysis: Employed as a model substrate in academic and industrial research to study fluorination reactions, C-H activation, and cross-coupling methodologies.
• Dye and Pigment Industry: Acts as an intermediate for synthesizing specialized fluorinated dyes and pigments with improved lightfastness and chemical resistance.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing high-value, low-volume specialty chemicals for clients.

Basic Information

Product Name	2',3',5',6'-Tetrafluoroacetanilide
CAS No.	1766-14-9
Molecular Formula	C8H5F4NO
Molecular Weight	207.13 g/mol
Synonyms	N-(2,3,5,6-Tetrafluorophenyl)acetamide; 2,3,5,6-Tetrafluoroacetanilide; Acetamide, N-(2,3,5,6-tetrafluorophenyl)-; 2,3,5,6-Tetrafluoro-N-phenylacetamide; Tetrafluoroacetanilide; Perfluoroacetanilide (common name); TFAA (abbreviation); 1766-14-9 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2',3',5',6'-Tetrafluoroacetanilide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets exacting research and process chemistry standards. A detailed Certificate of Analysis (COA) with batch-specific data is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.