Description

4,4,4-Trifluoro-3-(Trifluoromethyl)Crotonic Acid is a highly fluorinated, unsaturated carboxylic acid derivative. This compound matters as a versatile and valuable building block in advanced organic synthesis, prized for its ability to introduce multiple fluorine atoms and reactive functionality into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms contribute to improved biological activity and environmental stability.
• Fluorinated Polymer Precursor: Serves as a monomer or co-monomer in the synthesis of specialty polymers with unique surface properties, chemical resistance, and thermal stability.
• Liquid Crystal & OLED Material Research: Employed in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic display applications.
• Catalyst & Ligand Development: Acts as a precursor for creating novel fluorinated ligands used in asymmetric catalysis and transition metal complexes.
• Advanced Material Science: Utilized in surface modification and the creation of fluorinated coatings with hydrophobic and oleophobic characteristics.

Basic Information

Product Name	4,4,4-Trifluoro-3-(Trifluoromethyl)Crotonic Acid
CAS No.	1763-28-6
Molecular Formula	C5H2F6O2
Molecular Weight	208.06 g/mol
Synonyms	3-(Trifluoromethyl)-4,4,4-trifluorocrotonic Acid; 4,4,4-Trifluoro-3-(trifluoromethyl)-2-butenoic Acid; (E)-4,4,4-Trifluoro-3-(trifluoromethyl)but-2-enoic Acid; 2-Butenoic acid, 4,4,4-trifluoro-3-(trifluoromethyl)-; Perfluoroisocrotonic Acid; TFCA; TFTCA; Hexafluoroisocrotonic Acid
EINECS	217-179-3

Quality Control

Our 4,4,4-Trifluoro-3-(Trifluoromethyl)Crotonic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency. Standard quality parameters include assay (by HPLC), identification (IR, NMR), and control of key impurities. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against predefined specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed when not in use. Recommended long-term storage temperature is between 2°C and 8°C. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.