Description

6-Hydroxychlorzoxazone is a key pharmaceutical intermediate and metabolite of the centrally acting muscle relaxant chlorzoxazone. This compound is of significant importance in the development and quality control of therapeutic agents, serving as a critical reference standard for analytical and research purposes. It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, pharmacokinetic analysis, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of the active metabolite in bioanalytical studies.
• Drug Metabolism Research: Essential for in vitro and in vivo studies investigating the metabolic pathways and pharmacokinetics of chlorzoxazone.
• Impurity Profiling: Serves as a known impurity standard in the quality control of chlorzoxazone active pharmaceutical ingredient (API) and finished dosage forms.
• Analytical Method Development: Utilized for developing and validating HPLC, LC-MS, and other chromatographic methods in pharmaceutical analysis.
• Clinical Toxicology: Applied as a calibrator in assays monitoring chlorzoxazone metabolite levels for therapeutic drug monitoring or forensic analysis.
• Biochemical Research: Employed in studies exploring the mechanism of action and enzymatic interactions related to muscle relaxation.

Basic Information

Product Name	6-Hydroxychlorzoxazone
CAS No.	1750-45-4
Molecular Formula	C7H4ClNO3
Molecular Weight	185.56 g/mol
Synonyms	6-Hydroxychlorzoxazone; 5-Chloro-2-hydroxybenzoxazol-6-ol; 6-Hydroxy-5-chloro-2-benzoxazolinone; Chlorzoxazone Metabolite; 6-OH Chlorzoxazone; 5-Chloro-6-hydroxy-2-benzoxazolinone; 6-Hydroxy-5-chlorobenzoxazolin-2-one; SKF-30310 (Metabolite)
EINECS	Contact for details

Quality Control

Our 6-Hydroxychlorzoxazone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets high-purity standards suitable for pharmaceutical research and reference applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.