Description

Z-Gly-Onp is a protected amino acid derivative, specifically N-(Benzyloxycarbonyl)glycine 4-nitrophenyl ester, widely used as a key building block in peptide synthesis. This compound is valued for its role in facilitating efficient amide bond formation, enabling the controlled construction of complex peptide chains. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester, it is used for the controlled incorporation of glycine residues into growing peptide sequences.
• Solution-Phase Peptide Synthesis: Employed in classical coupling reactions for the synthesis of specific dipeptides or short peptide fragments.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to attach glycine or peptide motifs to other molecules, such as proteins, polymers, or surfaces, for creating functionalized biomaterials.
• Biochemical Research: A valuable tool for studying enzyme mechanisms, particularly those of proteases and peptidases, and for probing protein-protein interactions.
• Fine Chemical Synthesis: Acts as a specialized reagent for the synthesis of non-peptide compounds requiring the introduction of a protected glycyl moiety.

Basic Information

Product Name	Z-Gly-Onp
CAS No.	1738-86-9
Molecular Formula	C16H14N2O6
Molecular Weight	330.29 g/mol
Synonyms	N-Cbz-Glycine 4-Nitrophenyl Ester; N-(Benzyloxycarbonyl)glycine 4-nitrophenyl ester; Z-Gly-ONp; Cbz-Gly-ONp; N-Carbobenzoxyglycine p-nitrophenyl ester; Glycine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; Benzyl N-(4-nitrophenoxycarbonyl)glycinate
EINECS	217-095-6

Quality Control

Our Z-Gly-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and loss on drying for moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.