Description

Fluphenazine Sulfoxide is a key pharmaceutical intermediate and metabolite of the antipsychotic agent fluphenazine. Its precise chemical structure makes it an essential reference standard for analytical research, quality control, and metabolic studies within the pharmaceutical industry. This compound is primarily utilized by research institutions, analytical laboratories, and pharmaceutical manufacturers engaged in drug development and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the identification and quantification of fluphenazine and its related substances in drug products and biological samples.
• Metabolite Research: Used in pharmacokinetic and metabolic pathway studies to understand the biotransformation of fluphenazine in the body.
• Analytical Method Development: Employed as a benchmark in developing and validating high-performance liquid chromatography (HPLC), LC-MS, and other analytical methods.
• Impurity Profiling: Essential for monitoring and controlling process-related impurities and degradation products in fluphenazine API (Active Pharmaceutical Ingredient) manufacturing.
• Quality Assurance/Quality Control (QA/QC): A vital component in the quality control laboratories of pharmaceutical companies to ensure batch-to-batch consistency and compliance with pharmacopeial standards (e.g., USP, EP).
• Academic and Clinical Research: Supports investigative studies in neuropharmacology and the mechanism of action of phenothiazine-derived antipsychotics.

Basic Information

Product Name	Fluphenazine Sulfoxide
CAS No.	1674-76-6
Molecular Formula	C22H26F3N3OS
Molecular Weight	437.52 g/mol
Synonyms	10-[3-[4-(2-Hydroxyethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)-10H-phenothiazine 5-oxide; Fluphenazine S-Oxide; Fluphenazine Sulfoxide; Flufenazin Sulfoxide; Prolixin Sulfoxide; Fluphenazine Sulfoxide CRS (EP Reference Standard); Fluphenazine Related Compound C (USP); SQ 4918
EINECS	Contact for details

Quality Control

Our Fluphenazine Sulfoxide is manufactured and handled under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC. We provide supporting Certificates of Analysis (COA) detailing all test results and confirming compliance with in-house specifications tailored for use as a reference material. Specifications can be aligned with pharmacopeial guidelines (USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.