Description

N,n-Bis(2,4-Dinitrophenyl)-L-Histidine is a specialized, high-purity derivative of the amino acid L-histidine, modified with dinitrophenyl groups. This compound is valued for its role as a key intermediate in advanced organic synthesis and biochemical research, particularly in the development of enzyme inhibitors and affinity labeling reagents. It serves critical needs in pharmaceutical R&D, academic research institutions, and fine chemical manufacturing for producing targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel enzyme inhibitors and targeted therapeutic agents.
• Biochemical Research: Serves as a critical reagent for affinity labeling studies to investigate enzyme active sites and protein interactions.
• Proteomics & Chemical Biology: Employed in the development of chemical probes for studying histidine-related biological pathways and post-translational modifications.
• Fine Chemical Synthesis: Acts as a specialized building block for constructing complex molecules in custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and bioorganic mechanisms.

Basic Information

Product Name	N,n-Bis(2,4-Dinitrophenyl)-L-Histidine
CAS No.	1655-66-9
Molecular Formula	C18H14N8O8
Molecular Weight	446.35 g/mol
Synonyms	L-Histidine, N,N-bis(2,4-dinitrophenyl)-; Bis(2,4-dinitrophenyl)histidine; 2,4-Dinitrophenyl-L-histidine derivative; DNP-His; N,N'-Di(2,4-dinitrophenyl)-L-histidine; (2S)-2-Amino-3-[1-[[(2,4-dinitrophenyl)amino]-[(2,4-dinitrophenyl)imino]methyl]-4-imidazolyl]propanoic acid; Histidine DNP derivative
EINECS	Contact for details

Quality Control

Our N,n-Bis(2,4-Dinitrophenyl)-L-Histidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.