Description

n-Desmethylquazepam is a key benzodiazepine derivative and a primary metabolite of the pharmaceutical agent quazepam. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of active pharmaceutical ingredients (APIs). It serves as a critical reference standard and intermediate for analytical laboratories, research institutions, and manufacturers engaged in the development of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of quazepam and its metabolites in bioanalytical studies.
• Metabolite Research: Essential for pharmacokinetic and metabolic pathway studies to understand the biotransformation and clearance of benzodiazepine drugs.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a high-purity synthetic building block in the controlled production of specialized benzodiazepine-based pharmaceuticals.
• Forensic and Clinical Toxicology: Employed as an analytical standard for the accurate detection and quantification of benzodiazepines in forensic investigations and clinical toxicology reports.
• Biomedical Research: Utilized in preclinical research to investigate the pharmacological profile, receptor binding, and structure-activity relationships (SAR) of benzodiazepine analogs.
• Quality Control & Method Development: Critical for developing and validating analytical methods (e.g., HPLC, LC-MS/MS) in pharmaceutical quality control laboratories.

Basic Information

Product Name	n-Desmethylquazepam
CAS No.	1645-32-5
Molecular Formula	C₁₇H₁₁ClF₄N₂S
Molecular Weight	386.79 g/mol
Synonyms	7-Chloro-1-(2,2,2-trifluoroethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione; 2H-1,4-Benzodiazepine-2-thione, 7-chloro-1-(2,2,2-trifluoroethyl)-5-(2-fluorophenyl)-1,3-dihydro-; Desmethylquazepam; Norquazepam; F-3665; Quazepam Metabolite
EINECS	Contact for details

Quality Control

Our n-Desmethylquazepam is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, with testing performed using validated analytical methods including HPLC and spectroscopic techniques. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.