Description

(2R,4S)-4-Hydroxypiperidine-2-Carboxylic Acid CAS NO 1622-20-4 is a high-purity, chiral piperidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its dual functional groups, which make it a versatile intermediate for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) and metabolic diseases.
• Asymmetric Catalyst Precursor: Used to develop and manufacture chiral ligands and organocatalysts for enantioselective synthesis.
• Peptidomimetic Research: Incorporated into peptide backbones to create conformationally constrained analogs with enhanced stability and biological activity.
• Agrochemical Synthesis: Serves as a building block for creating advanced, stereochemically defined active ingredients.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Custom Synthesis: Basis for producing tailored fine chemicals and specialty intermediates for client-specific projects.

Basic Information

Product Name	(2R,4S)-4-Hydroxypiperidine-2-Carboxylic Acid
CAS No.	1622-20-4
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(2R,4S)-4-Hydroxy-2-piperidinecarboxylic Acid; (2R,4S)-4-Hydroxypipecolic Acid; cis-4-Hydroxy-D-pipecolic Acid; (2R,4S)-HPA; 4-Hydroxy-D-pipecolic Acid; 4-Hydroxy-L-pipecolic Acid enantiomer; 1622-20-4; 4-Hydroxypipecolic Acid
EINECS	Contact for details

Quality Control

Every batch of (2R,4S)-4-Hydroxypiperidine-2-Carboxylic Acid is produced under a strict quality management system. We employ advanced analytical techniques, including chiral HPLC and NMR, to guarantee high enantiomeric excess (ee) and chemical purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.