Description

Uracil, 6-(Fluoromethyl)- (6Ci,8Ci) is a fluorinated derivative of the nucleobase uracil, serving as a key synthetic intermediate in advanced organic and medicinal chemistry. This compound is valued for its role in introducing fluorine atoms into heterocyclic systems, a critical modification for tuning the biological activity and metabolic stability of target molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel nucleoside analogs, antiviral agents, and other bioactive compounds where fluorination is a strategic design element.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated nucleoside analogs and prodrugs with potential antiviral or anticancer activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluoromethyl substitution on binding affinity and pharmacokinetic properties.
• Biochemical Probe Development: Serves as a precursor for labeled compounds used to study enzyme mechanisms, particularly those involving thymidylate synthase or other pyrimidine metabolism pathways.
• Agrochemical Synthesis: Employed in the research and development of novel fluorinated pesticides or herbicides, leveraging fluorine's ability to enhance compound stability and membrane permeability.
• Organic Synthesis Building Block: Utilized in various fluorination strategies and cross-coupling reactions to construct complex heterocyclic scaffolds for material science or chemical biology applications.

Basic Information

Product Name	Uracil, 6-(Fluoromethyl)- (6Ci,8Ci)
CAS No.	1598-64-7
Molecular Formula	C5H5FN2O2
Molecular Weight	144.10 g/mol
Synonyms	6-(Fluoromethyl)uracil; 6-Fluoromethyluracil; 5-Fluoro-6-hydroxymethyluracil; 6-Fluoromethyl-2,4(1H,3H)-pyrimidinedione; 2,4-Dihydroxy-6-(fluoromethyl)pyrimidine; 6-Fluoromethyl-1H-pyrimidine-2,4-dione; 1,2,3,4-Tetrahydro-6-(fluoromethyl)-2,4-dioxopyrimidine
EINECS	Contact for details

Quality Control

Our Uracil, 6-(Fluoromethyl)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure consistency and reliability for research applications. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.