Description

n-Trifluoroacetyl-L-Cysteine Methyl Ester is a key chiral building block and derivatization reagent used in advanced organic synthesis and analytical chemistry. Its primary value lies in its role as a protected cysteine derivative, facilitating the synthesis of complex peptides and enabling the sensitive detection and analysis of thiol-containing compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly for developing active pharmaceutical ingredients (APIs) and diagnostic agents.

Application

• Peptide Synthesis: Serves as a crucial protected intermediate for the solid-phase and solution-phase synthesis of cysteine-containing peptides and proteins.
• Analytical Derivatization: Used as a derivatizing agent for the HPLC and LC-MS analysis of thiols, cysteamine, and other sulfur-containing biomolecules to enhance detection sensitivity.
• Pharmaceutical Intermediate: Acts as a key chiral building block in the research and production of novel therapeutic compounds, including protease inhibitors and other targeted therapies.
• Bioconjugation Chemistry: Facilitates the site-specific modification of proteins and antibodies for drug delivery systems and diagnostic probes.
• Biochemical Research: Employed in studies of redox biology, enzyme mechanisms, and protein structure-function relationships involving cysteine residues.
• Reference Standard: Used as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Item	Detail
Product Name	n-Trifluoroacetyl-L-Cysteine Methyl Ester
CAS No.	1577-62-4
Molecular Formula	C7H8F3NO3S
Molecular Weight	243.20 g/mol
Synonyms	N-(Trifluoroacetyl)-L-cysteine methyl ester; L-Cysteine, N-(trifluoroacetyl)-, methyl ester; Methyl N-trifluoroacetyl-L-cysteinate; TFA-Cys-OMe; N-TFA-L-cysteine methyl ester; (R)-Methyl 2-(2,2,2-trifluoroacetamido)-3-mercaptopropanoate; Trifluoroacetylcysteine methyl ester; 1577-62-4
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyl-L-Cysteine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.