Description

Trifluoperazine Sulfoxide is a key pharmaceutical intermediate and metabolite of the antipsychotic agent trifluoperazine. Its precise chemical structure makes it a critical reference standard and building block for analytical research and drug development. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in neuropharmacology studies, quality control, and metabolic pathway analysis.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of trifluoperazine and its metabolites in drug substance and product analysis.
• Metabolite Research: Essential for studying the pharmacokinetics, metabolic pathways, and bioavailability of the parent drug trifluoperazine in preclinical and clinical research.
• Analytical Method Development: Serves as a critical component in developing and validating analytical methods, such as HPLC, LC-MS, and GC-MS, for impurity profiling and stability studies.
• Process Chemistry Intermediate: Employed in the synthesis and scale-up of related phenothiazine derivatives for pharmaceutical manufacturing.
• Quality Control & Assurance: Used by QC laboratories to ensure the purity, identity, and consistency of trifluoperazine-based active pharmaceutical ingredients (APIs) and finished dosage forms.
• Toxicological Studies: Applied in forensic and clinical toxicology to investigate drug exposure and metabolic fate.

Basic Information

Product Name	Trifluoperazine Sulfoxide
CAS No.	1549-88-8
Molecular Formula	C21H24F3N3OS
Molecular Weight	423.50 g/mol
Synonyms	10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine 5-oxide; Trifluoperazine S-Oxide; Trifluoperazine Sulfoxide; Trifluoperazine 5-Oxide; SKF 6075; NSC 113929; Trifluoperazine Metabolite Sulfoxide; 2-Trifluoromethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine 5-oxide
EINECS	Contact for details

Quality Control

Our Trifluoperazine Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of related substances, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.