Description

4,4,4-Trifluoro-3-Hydroxy-1-Phenylbutane-1-One is a high-value fluorinated organic building block characterized by its unique trifluoromethyl and β-hydroxy ketone functional groups. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity, metabolic stability, and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in CNS and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the CF3 group enhances efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated monomers for specialty polymers with unique surface properties.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products for metabolic pathway studies.
• Academic & Industrial R&D: A versatile building block for exploratory chemistry in medicinal and synthetic organic chemistry laboratories.

Basic Information

Product Name	4,4,4-Trifluoro-3-Hydroxy-1-Phenylbutane-1-One
CAS No.	1524-15-8
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	1-Phenyl-4,4,4-trifluoro-3-hydroxybutan-1-one; 4,4,4-Trifluoro-3-hydroxybutyrophenone; 3-Hydroxy-4,4,4-trifluorobutyrophenone; 4,4,4-Trifluoro-3-hydroxy-1-phenylbutan-1-one; TFHBP; α-(Trifluoromethyl)-β-hydroxypropiophenone; β-Hydroxy-β-trifluoromethylpropiophenone; (RS)-4,4,4-Trifluoro-3-hydroxy-1-phenylbutan-1-one
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-3-Hydroxy-1-Phenylbutane-1-One is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent lot-to-lot performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	88 - 92 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.