Description

2-Bromo-5-(Trifluoromethyl)Benzonitrile is a versatile and high-value aromatic nitrile building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in cross-coupling reactions, ligand synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Material Science: Serves as a precursor for liquid crystals, organic semiconductors, and polymers where the bromine atom facilitates further functionalization via metal-catalyzed coupling.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and heteroaryl structures.
• Ligand & Catalyst Development: Employed in the design and synthesis of novel phosphine and N-heterocyclic carbene (NHC) ligands for catalysis.
• Chemical Biology & Proteomics: Used as a building block for activity-based probes and molecular tags due to its reactive bromine handle.

Basic Information

Product Name	2-Bromo-5-(Trifluoromethyl)Benzonitrile
CAS No.	1483-55-2
Molecular Formula	C8H3BrF3N
Molecular Weight	250.02 g/mol
Synonyms	2-Bromo-α,α,α-trifluoro-p-tolunitrile; 5-(Trifluoromethyl)-2-bromobenzonitrile; 2-Bromo-5-(trifluoromethyl)benzonitrile; 2-Bromo-α,α,α-trifluoro-4-cyanotoluene; 4-Bromo-2-cyanobenzotrifluoride; 2-Bromo-α,α,α-trifluoro-p-cyanotoluene; Benzonitrile, 2-bromo-5-(trifluoromethyl)-; p-Cyanobenzotrifluoride, 2-bromo-
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.