Description

n-(Trifluoroacetyl)-L-Valine Butyl Ester is a protected amino acid derivative, specifically a trifluoroacetylated valine ester. This compound is a crucial chiral building block and protecting group reagent in sophisticated organic synthesis, particularly for peptides and pharmaceuticals. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis, where the trifluoroacetyl (TFA) group serves as a temporary amine protector.
• Agrochemical Research: Employed as a building block for developing novel chiral pesticides and herbicides with enhanced specificity.
• Bioconjugation Chemistry: Facilitates the site-specific modification of biomolecules for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: Serves as a precursor for chiral ligands or catalysts used in enantioselective transformations.
• Chemical Biology & Proteomics: Used in activity-based protein profiling (ABPP) and other chemical proteomics studies to investigate enzyme function.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Valine Butyl Ester
CAS No.	1478-96-2
Molecular Formula	C11H18F3NO3
Molecular Weight	269.26 g/mol
Synonyms	L-Valine, N-[(trifluoroacetyl)-, butyl ester; Butyl N-(trifluoroacetyl)-L-valinate; N-(Trifluoroacetyl)valine butyl ester; N-TFA-L-valine butyl ester; (S)-2-((Trifluoroacetyl)amino)-3-methylbutanoic acid butyl ester; Butyl (2S)-2-[(2,2,2-trifluoroacetyl)amino]-3-methylbutanoate; Valine, N-trifluoroacetyl-, butyl ester, L-; TFA-L-Val-OBu
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Valine Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.