Description

Mitogillin is a potent protein synthesis inhibitor belonging to the class of ribosome-inactivating proteins (RIPs), specifically a type I RIP. This compound is of significant interest in biochemical and pharmacological research due to its specific mechanism of action on the 28S ribosomal RNA. It serves as a critical tool for researchers in molecular biology, oncology, and toxicology studying protein synthesis inhibition, targeted cell death, and the development of immunotoxins. Its high purity and stability are essential for reproducible experimental results in these advanced applications.

Application

• Biochemical Research: Used as a specific inhibitor of eukaryotic protein synthesis to study ribosome function and the mechanisms of translation.
• Oncology Research: Investigated for its potential in constructing immunotoxins and antibody-drug conjugates (ADCs) for targeted cancer therapy.
• Cell Biology Studies: Employed to induce selective cell death in vitro to understand apoptosis and cellular stress pathways.
• Toxicology: Serves as a model compound for studying the effects of ribosome-inactivating proteins.
• Enzyme Studies: Used to investigate the enzymatic activity and structure-function relationships of type I RIPs.
• Plant Pathology Research: Studied for its natural role as a mycotoxin and its interactions with host organisms.

Basic Information

Product Name	Mitogillin
CAS No.	1403-99-2
Molecular Formula	C19H29N5O7
Molecular Weight	439.46 g/mol
Synonyms	Restrictocin; Aspergillus restrictus ribonuclease; Mitogillin (RNase mitogillin); Ribonuclease mitogillin; EINECS 215-772-5; RNase mitogillin; Restrictocin (Aspergillus restrictus)
EINECS	215-772-5

Quality Control

Our Mitogillin is produced and tested under stringent quality management protocols to ensure the highest standards of purity and biological activity required for research applications. Each batch is characterized using advanced analytical techniques, including HPLC for purity and bioassays for functional activity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, potency, and safety data is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Protein Content (Biuret)	≥ 90.0%
Biological Activity (Cell-free assay)	≥ 90% of reference standard
Endotoxin Level (LAL)	< 1.0 EU/μg
Solubility	Soluble in water and buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.