Description

Z-Gly-Phe-Oh is a protected dipeptide building block, specifically the benzyloxycarbonyl (Z) derivative of the glycyl-phenylalanine dipeptide. This compound is a crucial intermediate in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains with high fidelity. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers for the production of therapeutic peptides, research biochemicals, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled, sequential assembly of longer peptide sequences in both research and GMP manufacturing.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic, oncological, and neurological disorders.
• Biochemical Research: Used in enzymatic studies, substrate specificity assays, and as a standard in analytical method development for peptide analysis.
• Protecting Group Chemistry: The Z-group (Cbz) provides amine protection during synthetic steps and can be selectively removed under mild hydrogenolytic conditions.
• Custom Peptide Service: A standard reagent used by CROs and CDMOs for the custom synthesis of peptides for clients in academia and industry.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening applications.

Basic Information

Product Name	Z-Gly-Phe-Oh
CAS No.	1170-76-9
Molecular Formula	C19H20N2O5
Molecular Weight	356.37 g/mol
Synonyms	N-Carbobenzoxy-glycyl-L-phenylalanine; Cbz-Gly-L-Phe-OH; Z-Gly-L-Phe-OH; N-(Benzyloxycarbonyl)glycyl-L-phenylalanine; Benzyl N-[(benzyloxy)carbonyl]glycyl-L-phenylalaninate; N-Cbz-glycyl-L-phenylalanine; (2S)-2-[[2-[(Phenylmethoxy)carbonylamino]acetyl]amino]-3-phenylpropanoic acid; CBZ-Gly-Phe-OH
EINECS	214-585-5

Quality Control

Our Z-Gly-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing identity, purity (assay), and specific impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% L-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.