Description

2-Chlorobenzylamiloride is a specialized chemical compound belonging to the amiloride class of molecules, which are known for their role as sodium channel blockers. This compound matters for its utility as a key intermediate and research chemical in the development of novel pharmaceuticals and biochemical tools. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on cardiovascular, renal, and diuretic agent research.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced drug candidates, particularly those targeting ion channels.
• Biochemical Research: Used as a reference standard or active agent in studies investigating epithelial sodium channel (ENaC) activity and related physiological pathways.
• Life Science Reagents: Incorporated into specialized kits and reagents for cellular and molecular biology research applications.
• Academic & Contract Research: Employed in university and CRO settings for mechanistic studies and the discovery of new therapeutic agents.

Basic Information

Product Name	2-Chlorobenzylamiloride
CAS No.	1163-44-6
Molecular Formula	C12H11Cl2N3O
Molecular Weight	284.14 g/mol
Synonyms	2-Chloroamiloride; 2-Chlorobenzylamiloride; 3,5-Diamino-6-chloro-N-(2-chlorobenzyl)pyrazine-2-carboxamide; 6-Chloro-3,5-diamino-N-(2-chlorobenzyl)pyrazine-2-carboxamide; Amiloride, 2-chloro-; 2-Chloroamiloride Hydrochloride (common salt form); 2-CBA (abbreviation); BZA-2Cl (research code)
EINECS	Contact for details

Quality Control

Our 2-Chlorobenzylamiloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.