Description

n-Cbz-L-Phenylalanine CAS NO 1161-13-3 is a protected derivative of the essential amino acid L-phenylalanine, featuring a carboxybenzyl (Cbz) protecting group on the amine functionality. This compound is a critical building block in the synthesis of peptides and other bioactive molecules, offering a versatile and orthogonal protecting group strategy. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for the development of peptide-based therapeutics, diagnostic agents, and advanced research chemicals.

Application

• Peptide Synthesis: A fundamental intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled elongation of peptide chains.
• Pharmaceutical Intermediates: Serves as a key chiral precursor in the manufacture of active pharmaceutical ingredients (APIs) and peptidomimetics.
• Bioconjugation: Used in the preparation of peptide-protein conjugates for drug delivery systems and diagnostic probes.
• Research & Development: Essential for academic and industrial R&D in medicinal chemistry, biochemistry, and chemical biology.
• Fine Chemical Production: Employed in the synthesis of complex organic molecules and specialty chemicals requiring protected amino acid motifs.
• Enzyme Substrate Analogues: Acts as a substrate or inhibitor in enzymatic studies and assay development.

Basic Information

Product Name	n-Cbz-L-Phenylalanine
CAS No.	1161-13-3
Molecular Formula	C17H17NO4
Molecular Weight	299.32 g/mol
Synonyms	N-Carbobenzoxy-L-phenylalanine; N-Benzyloxycarbonyl-L-phenylalanine; Z-L-Phenylalanine; Z-Phe-OH; (S)-2-(((Benzyloxy)carbonyl)amino)-3-phenylpropanoic acid; CBZ-L-Phenylalanine; NSC 3349; L-Phenylalanine, N-[(phenylmethoxy)carbonyl]-
EINECS	214-567-4

Quality Control

Our n-Cbz-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing specifications such as assay, optical rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]	-15.0° to -18.0° (c=1 in DMF)
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.