Description

Tos-Arg-Oh CAS NO 1159-15-5 is a protected arginine derivative, specifically the tosyl (Tos) derivative of arginine. This compound is a critical building block in peptide synthesis, where it serves to protect the guanidino group of arginine from side reactions during coupling steps. It is an essential reagent for researchers and manufacturers in pharmaceutical development, biochemistry, and proteomics who require high-purity, reliable intermediates for constructing complex peptide sequences.

Application

• Peptide Synthesis: A key protected amino acid for the solid-phase and solution-phase synthesis of peptides containing arginine residues.
• Pharmaceutical Intermediates: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Biochemical Research: Employed in the study of protein-protein interactions, enzyme substrates, and signal transduction pathways by incorporating modified arginine.
• Proteomics & Labeling: Serves as a precursor for introducing specialized tags or functional groups onto peptides for analytical and diagnostic purposes.
• Custom Peptide Production: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Tos-Arg-Oh
CAS No.	1159-15-5
Molecular Formula	C13H20N4O4S
Molecular Weight	328.39 g/mol
Synonyms	NG-Tosyl-L-arginine; L-Arginine, N2-[(4-methylphenyl)sulfonyl]-; Nω-Tosyl-L-arginine; NG-Tos-L-Arg-OH; Tos-Arg-OH; TOSYL-L-ARGININE; H-Arg(Tos)-OH; Nω-p-Toluenesulfonyl-L-arginine
EINECS	214-574-9

Quality Control

Our Tos-Arg-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance in GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -12.0° (c=1 in 1N HCl)
Chiral Purity (HPLC)	≥99.0% L-isomer
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.