Description

n-Cbz-L-Serine is a protected amino acid derivative essential for advanced organic synthesis and peptide chemistry. Its primary value lies in the orthogonal protection strategy it enables, where the Cbz (carboxybenzyl) group safeguards the amine functionality while allowing for selective manipulation of the serine side chain. This compound is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of peptide-based therapeutics, complex natural products, and novel drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled, sequential assembly of peptides, especially those containing serine residues.
• Solution-Phase Peptide Coupling: Used in classical peptide bond formation reactions for research-scale and industrial production of specific peptide sequences.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs that incorporate serine.
• Bioconjugation and Linker Chemistry: The carboxylic acid and protected amine groups provide handles for creating custom linkers or attaching peptides to other molecules, surfaces, or carriers.
• Chemical Biology Research: Employed in the synthesis of peptide probes, enzyme substrates, inhibitors, and other tools for studying biological processes.
• Synthesis of Modified Amino Acids: Used as a starting material for preparing serine analogs with tailored properties for structure-activity relationship (SAR) studies.

Basic Information

Product Name	n-Cbz-L-Serine
CAS No.	1145-80-8
Molecular Formula	C11H13NO5
Molecular Weight	239.22 g/mol
Synonyms	N-Carboxybenzyl-L-serine; N-Cbz-L-serine; N-[(Benzyloxy)carbonyl]-L-serine; (S)-2-(((Benzyloxy)carbonyl)amino)-3-hydroxypropanoic acid; Z-L-Serine; Z-Ser-OH; CBZ-L-Serine; L-Serine, N-[(phenylmethoxy)carbonyl]-
EINECS	214-545-9

Quality Control

Our n-Cbz-L-Serine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for chiral purity and chemical assay, alongside identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications. We support cGMP manufacturing requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.