Description

Diethyl L-Glutamate Hydrochloride is a protected derivative of the essential amino acid L-glutamic acid, widely used as a key chiral building block in organic synthesis. This compound is crucial for researchers and manufacturers requiring high-purity intermediates for the production of peptides, pharmaceuticals, and fine chemicals. It is particularly valuable for the pharmaceutical, biotechnology, and advanced materials sectors, where precise stereochemistry and reliable quality are paramount.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of peptide-based drugs, neurological agents, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected glutamic acid residue in solid-phase and solution-phase peptide synthesis, enabling the construction of complex polypeptides.
• Biochemical Research: Used as a standard or reagent in metabolic studies, enzyme substrate research, and neuroscience investigations related to glutamate pathways.
• Fine Chemical Production: An important intermediate for manufacturing specialty chemicals, including flavors, fragrances, and advanced polymer precursors.
• Cosmetic Ingredient Synthesis: Employed in the development of certain moisturizing and skin-conditioning agents derived from amino acids.

Basic Information

Item	Detail
Product Name	Diethyl L-Glutamate Hydrochloride
CAS No.	1118-89-4
Molecular Formula	C9H18ClNO4
Molecular Weight	239.70 g/mol
Synonyms	L-Glutamic Acid Diethyl Ester Hydrochloride; H-Glu(OEt)-OEt·HCl; Diethyl L-Glutamate HCl; Diethyl (S)-2-Aminopentanedioate Hydrochloride; (S)-2-Amino-1,5-diethoxy-1,5-dioxopentan-2-aminium Chloride; Glutamic Acid Diethyl Ester Hydrochloride; Ethyl L-Glutamate Hydrochloride
EINECS	214-268-7

Quality Control

Our Diethyl L-Glutamate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	+19.0° to +23.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.