Description

6-α-Fluorhydrocortisone is a synthetic fluorinated corticosteroid derivative, a key intermediate in the synthesis of more potent topical and systemic anti-inflammatory pharmaceuticals. Its value lies in providing a critical structural scaffold for developing advanced steroid-based therapeutics with enhanced activity and specificity. This compound is essential for pharmaceutical R&D laboratories and manufacturers focused on producing corticosteroid APIs, dermatological preparations, and specialized hormonal treatments.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of potent topical corticosteroids like fludrocortisone acetate and other fluorinated steroid drugs.
• Anti-inflammatory Drug Research: Used in preclinical and research settings to study structure-activity relationships (SAR) of fluorinated glucocorticoids.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical laboratories.
• Metabolic Pathway Studies: Employed in biochemical research to investigate steroid metabolism and enzyme inhibition.
• Dermatological Formulation Development: Used in the development of creams, ointments, and lotions targeting inflammatory skin conditions.
• Veterinary Pharmaceutical Synthesis: An intermediate in the production of anti-inflammatory and immunosuppressive drugs for veterinary medicine.

Basic Information

Product Name	6-α-Fluorhydrocortisone
CAS No.	1053-58-3
Molecular Formula	C21H29FO5
Molecular Weight	380.45 g/mol
Synonyms	6α-Fluorohydrocortisone; 6α-Fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione; 6α-Fluorocortisol; 6-Fluorohydrocortisone; 6α-Fluoro-17α-hydroxycorticosterone; 6α-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione; NSC 47432; Fludrocortisone intermediate
EINECS	213-889-5

Quality Control

Our 6-α-Fluorhydrocortisone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, IR and NMR for structural confirmation, and stringent control of related substances and residual solvents to meet exacting standards for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.