Description

(-)-Sotalol Hydrochloride CAS NO 1026-89-7 is the pure enantiomeric form of the β-adrenergic blocking agent, sotalol, formulated as its hydrochloride salt. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers and advanced research institutions focused on cardiovascular therapeutics and chiral chemistry studies.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure (R)-Sotalol, a Class III antiarrhythmic agent.
• Cardiovascular Drug Research: Used in preclinical and clinical research for studying β-blockade and potassium channel blocking effects.
• Chiral Reference Standard: Serves as a high-purity reference standard for analytical method development and quality control in API manufacturing.
• Metabolite Studies: Employed in the research of drug metabolism and pharmacokinetics (DMPK) for sotalol and related compounds.
• Formulation Development: Used in the development of solid dosage forms requiring the specific (-)-enantiomer.

Basic Information

Product Name	(-)-Sotalol Hydrochloride
CAS No.	1026-89-7
Molecular Formula	C12H20N2O3S•HCl
Molecular Weight	308.82 g/mol
Synonyms	(-)-Sotalol HCl; (R)-Sotalol Hydrochloride; L-Sotalol Hydrochloride; Sotalol (R)-Isomer Hydrochloride; N-{4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl}methanesulfonamide Hydrochloride; MJ 1999; β-Cardone (enantiomer); 4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide Hydrochloride
EINECS	Contact for details

Quality Control

Our (-)-Sotalol Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure high chemical and enantiomeric purity, meeting stringent standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, enantiomeric excess, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.