Description

2',2'-Difluoro-2'-Deoxycytidine-3',5'-Dibenzoate is a key fluorinated nucleoside derivative, serving as a crucial protected intermediate in the synthesis of advanced pharmaceutical compounds. Its primary commercial value lies in enabling the production of high-purity active pharmaceutical ingredients (APIs) with enhanced metabolic stability and therapeutic efficacy. This compound is essential for research institutions and manufacturers in the pharmaceutical and biotechnology sectors focused on antiviral and anticancer drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of nucleoside analog drugs, particularly gemcitabine and related chemotherapeutic agents.
• Antiviral Drug Research: Used in the development and scale-up of novel antiviral compounds targeting viral polymerases.
• Oncology Research: Serves as a precursor in the creation of fluorinated cytidine analogs for cancer treatment research.
• Process Chemistry: Employed in process development and optimization for the commercial manufacturing of fluorinated APIs.
• Biochemical Synthesis: Utilized in custom oligonucleotide synthesis and the preparation of labeled compounds for metabolic studies.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical production.

Basic Information

Product Name	2',2'-Difluoro-2'-Deoxycytidine-3',5'-Dibenzoate
CAS No.	147-87-5
Molecular Formula	C23H21F2N3O6
Molecular Weight	473.43 g/mol
Synonyms	2',2'-Difluoro-2'-deoxycytidine 3',5'-dibenzoate; 3',5'-Di-O-benzoyl-2',2'-difluoro-2'-deoxycytidine; 2'-Deoxy-2',2'-difluorocytidine 3',5'-dibenzoate; Gemcitabine 3',5'-Dibenzoate Intermediate; 1-(3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-D-erythro-pentofuranosyl)-4-amino-2(1H)-pyrimidinone; DFDC-DBz; 2'-Fluoro-2'-deoxycytidine derivative
EINECS	Contact for details

Quality Control

Our 2',2'-Difluoro-2'-Deoxycytidine-3',5'-Dibenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.