Description

Human Neutrophil Peptide-1 (HNP-1) is a potent antimicrobial peptide that plays a critical role in the innate immune defense system. This defensin is valued for its broad-spectrum activity against bacteria, fungi, and certain viruses, making it a key molecule of interest in immunology and therapeutic research. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for studying host-pathogen interactions and developing novel anti-infective agents.

Application

• Immunological Research: Fundamental studies on neutrophil function, innate immunity, and defensin mechanisms of action.
• Antimicrobial Agent Development: Serves as a lead compound or model for designing new peptide-based antibiotics and antifungals.
• Biomarker Investigation: Research into the role of HNP-1 as a biomarker for inflammatory and infectious diseases.
• Drug Delivery Systems: Exploration of HNP-1 in targeted delivery systems due to its membrane-active properties.
• Cosmeceutical Applications: Investigation of its potential in formulations aimed at skin microbiome balance and anti-acne products.
• Veterinary Medicine: Research for developing antimicrobial treatments in animal health.

Basic Information

Product Name	Human Neutrophil Peptide-1
CAS No.	99287-08-8
Molecular Formula	C147H238N44O37S6
Molecular Weight	3442.1 g/mol
Synonyms	HNP-1; Defensin, alpha 1; Neutrophil Defensin 1; HP-1; Human Neutrophil Peptide Defensin 1; DEFA1; MRS; HNP1; α-Defensin 1
EINECS	Contact for details

Quality Control

Our Human Neutrophil Peptide-1 is produced and tested under stringent quality management systems. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for purity (by HPLC), peptide content, endotoxin levels, and sterility where applicable, supporting research and pre-clinical development needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single-Chain Proportion	≥ 90%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Biological Activity	Determined by antimicrobial assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.