Description

L-tert-Leucinamide Hydrochloride is a high-purity chiral amino acid derivative, specifically the hydrochloride salt of L-tert-leucinamide. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, enabling the creation of active ingredients with high stereochemical purity. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery, process development, and the production of peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other therapeutic agents.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce the sterically hindered tert-leucine residue.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Catalyst & Ligand Preparation: Serves as a precursor for chiral auxiliaries, catalysts, and ligands used in enantioselective transformations.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-tert-Leucinamide Hydrochloride
CAS No.	75158-12-2
Molecular Formula	C7H17ClN2O
Molecular Weight	180.68 g/mol
Synonyms	(S)-2-Amino-3,3-dimethylbutanamide hydrochloride; L-2-Amino-3,3-dimethylbutyramide hydrochloride; (S)-2-Amino-3,3-dimethylbutyramide hydrochloride; L-tert-Butylglycinamide hydrochloride; tert-Leucinamide hydrochloride, L-; H-Tle-NH2·HCl; (S)-tert-Leucinamide hydrochloride
EINECS	Contact for details

Quality Control

Our L-tert-Leucinamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and identity (IR, NMR) are rigorously verified. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition (Sulfated Ash)	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.