Gastric Acid Secretion Inhibitors
Digestive System Drugs
- Liver Disease Drugs
- Antacids and Gastric Mucosal Protectants
- Choleretics
- Other Digestive System Drugs
- Appetite Suppressants and other Weight-loss Drugs
- Gastrointestinal Motility Agents
- Gastrointestinal Antispasmodics
- Laxatives and Antidiarrheals
- Gastric Acid Secretion Inhibitors
- Antiemetics and Emetics
- Digestant Drugs
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Gastric Acid Secretion Inhibitors
Gastric acid secretion inhibitors are key medications used to reduce gastric acid production by blocking histamine H2 receptors, inhibiting proton pumps, or interfering with gastrin-mediated pathways. Major drug classes include H2 receptor antagonists, proton pump inhibitors (PPIs), and potassium-competitive acid blockers (P-CABs). These agents are highly effective in treating peptic ulcer disease, gastroesophageal reflux disease, Zollinger–Ellison syndrome, and NSAID-induced gastric injury. Their mechanisms involve reducing acid secretion, promoting mucosal healing, and decreasing acid-related symptoms such as heartburn and epigastric pain. Long-term therapy may require monitoring for risks such as nutrient malabsorption, infections, or renal effects. Gastric acid secretion inhibitors remain foundational in modern gastrointestinal pharmacotherapy.
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