Description

Oxmetidine is a selective histamine H2-receptor antagonist with significant pharmacological research interest. This compound is valued for its role in studying gastric acid secretion and related physiological pathways. It serves as a critical intermediate and reference standard for pharmaceutical R&D, particularly in the development of anti-ulcer and gastrointestinal therapeutics. Researchers and manufacturers in the fine chemical and active pharmaceutical ingredient (API) sectors require this high-purity compound for synthesis and analytical purposes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced histamine H2-receptor antagonists.
• Biochemical Research: Used as a reference standard in pharmacological studies to investigate gastric acid secretion mechanisms.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• API Development: Employed in research and development pipelines for novel anti-ulcer and gastroprotective drug candidates.
• Academic Research: Utilized in university and institutional labs for studying receptor-ligand interactions and signal transduction pathways.

Basic Information

Product Name	Oxmetidine
CAS No.	72830-39-8
Molecular Formula	C13H19N5O2S
Molecular Weight	309.39 g/mol
Synonyms	SK&F 92994; 2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(2-hydroxyethyl)acetamide; 1-[2-[[[2-[(Diaminomethylene)amino]-1,3-thiazol-4-yl]methyl]thio]acetyl]-2-hydroxyethylamine; Oxmetidine Hydrochloride (salt form); Guanidinothiazole derivative; H2 antagonist SKF-92994
EINECS	Contact for details

Quality Control

Our Oxmetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specified impurities, to ensure it meets high-grade research and development standards. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.