Description

Icotidine CAS NO 71351-79-6 is a selective histamine H2-receptor antagonist, primarily recognized for its potent antisecretory activity. This compound is of significant interest in pharmaceutical research and development for its potential therapeutic applications. It is a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical industry, particularly those developing or producing gastrointestinal medications.

Application

• Pharmaceutical intermediate for the synthesis of advanced histamine H2-receptor antagonists.
• Reference standard in analytical laboratories for quality control and method validation.
• Active Pharmaceutical Ingredient (API) research and development for ulcer treatment.
• Biochemical research tool for studying gastric acid secretion mechanisms.
• Precursor in the development of novel gastroprotective agents.

Basic Information

Product Name	Icotidine
CAS No.	71351-79-6
Molecular Formula	C13H19N5O2S
Molecular Weight	309.39 g/mol
Synonyms	Icotidine; SK&F 93319; 2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N2-cyano-N-ethylacetamidine; 2-({[2-(Diaminomethylideneamino)-1,3-thiazol-4-yl]methyl}sulfanyl)-N-cyano-N'-ethylacetamidine
EINECS	Contact for details

Quality Control

Our Icotidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from tests including HPLC assay, related substances, residual solvents, and identification (IR). We can supply material compliant with various pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.