Description

Tiotidine CAS NO 69014-14-8 is a selective histamine H2-receptor antagonist. This compound is of significant interest in pharmaceutical research and development, particularly for investigating mechanisms related to gastric acid secretion. It serves as a critical intermediate and reference standard for the synthesis and analytical validation of novel therapeutic agents. Industries engaged in advanced pharmaceutical R&D, contract manufacturing, and fine chemical synthesis are the primary users of this high-purity material.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced H2-antagonist drug candidates and related pharmacologically active molecules.
• Biochemical Research: Used as a reference standard and tool compound in studies of histamine receptor function, signal transduction pathways, and gastrointestinal physiology.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for method development, validation, and quality control in analytical laboratories (HPLC, LC-MS).
• Preclinical Development: Employed in non-clinical studies to evaluate pharmacokinetics, metabolism, and safety profiles of new chemical entities targeting acid-related disorders.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and pharmacology.

Basic Information

Product Name	Tiotidine
CAS No.	69014-14-8
Molecular Formula	C13H20N4O3S2
Molecular Weight	344.45 g/mol
Synonyms	2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(2-[(diaminomethylene)amino]-4-thiazolyl)acetamide; Tiotidine; SK&F 92456; 2-({[2-(Carbamimidamido)-1,3-thiazol-4-yl]methyl}sulfanyl)-N-[2-(carbamimidamido)-1,3-thiazol-4-yl]acetamide; L-643,441
EINECS	Contact for details

Quality Control

Our Tiotidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. We provide full traceability and support regulatory submissions. Certificates of Analysis (COA) detailing purity (typically ≥98% by HPLC), related substances, and other critical parameters are available for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.