Alkylating Antineoplastic Agents

Antineoplastics

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Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

3-Hydroxy-13-Amino-13,17-Seco-5Alpha-Androstan-17-Oic-13,17-Lactam 2-N,n-Bis(2-Chloroethyl)Aminobenzoate CAS NO 157757-66-9

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CAS No.:157757-66-9

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(2R)-L-Gamma-Glutamyl-3-((2-((Bis(Bis(2-Chloroethyl)Amino)Phosphinyl)Oxy) Ethyl)Sulfonyl)- L-Alanyl-2-Phenylglycine CAS NO 158382-37-7

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CAS No.:158382-37-7

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17-o-((2-(3-(4-Azido-3-Iodophenyl)Propionamido)Ethyl)Carbamyl)Estradiol-3-n-Bis(Chloroethyl)Carbamate CAS NO 159899-37-3

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CAS No.:159899-37-3

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7-Beta(n-(2-Chloroethyl)-n-Nitroso-n-Carbonylaminoethyl)Cholesterol CAS NO 164120-26-7

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CAS No.:164120-26-7

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n-2-L-Arabinoliranoenyl-n-Methyl-n-Nitrosourea CAS NO 167396-23-8

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CAS No.:167396-23-8

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n-[Bis(2-Chloroethyl)Amino-Morpholin-4-Yl-Phosphoryl]Cyclohexanamine CAS NO 169811-10-3

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CAS No.:169811-10-3

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Cloretazine CAS NO 173424-77-6

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CAS No.:173424-77-6

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Ortho-Chlorambucil CAS NO 178481-89-5

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CAS No.:178481-89-5

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