Description

Ifosfamide CAS NO 3778-73-2 is a nitrogen mustard alkylating agent belonging to the oxazaphosphorine class of chemotherapeutic drugs. It is a critical active pharmaceutical ingredient (API) valued for its potent antineoplastic properties, primarily functioning by cross-linking DNA strands to inhibit tumor cell proliferation. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing chemotherapeutic regimens. Its primary application is in the formulation of injectable oncology drugs for treating various cancers, including sarcomas, lymphomas, and testicular cancer.

Application

• Oncological Drug Manufacturing: Primary use as the key active pharmaceutical ingredient (API) in the production of injectable chemotherapy formulations.
• Combination Cancer Therapy: Used in chemotherapeutic protocols alongside other agents like mesna (for uroprotection) for treating germ cell testicular cancer, soft tissue sarcoma, and bone sarcoma.
• Hematologic Malignancy Treatment: Formulation component for drugs targeting non-Hodgkin lymphoma and other specific lymphomas.
• Pediatric Oncology: Utilized in certain treatment regimens for pediatric solid tumors.
• Pharmaceutical Research & Development: Serves as a reference standard and key intermediate in developing new oncological therapeutics and delivery systems.
• Clinical Trial Material: Supplied as a high-purity bulk active substance for use in clinical studies and trials.
• Generic Drug Production: Sourced by manufacturers producing generic ifosfamide-based chemotherapy products.

Basic Information

Product Name	Ifosfamide
CAS No.	3778-73-2
Molecular Formula	C7H15Cl2N2O2P
Molecular Weight	261.09 g/mol
Synonyms	3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; Ifosfamidum; Ifosfamid; Holoxan; Ifex; Iso-Endoxan; Iphosphamide; MJF 9325; NSC-109724; Z-4942
EINECS	223-218-8

Quality Control

Our Ifosfamide is manufactured under strict quality management systems, ensuring it meets the stringent requirements for pharmaceutical active ingredients. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, in compliance with current pharmacopeial standards (e.g., USP, EP). A Certificate of Analysis (COA) documenting purity, physical characteristics, and test results is provided with every shipment to guarantee traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.