Description

o-Bis(2-Chloroethyl)Aminomethylphenylalanine Hydrochloride is a specialized nitrogen mustard derivative of phenylalanine, a key building block in medicinal chemistry research. This compound matters as a critical intermediate for the synthesis of targeted chemotherapeutic agents and for studying structure-activity relationships in drug development. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology and targeted therapy development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nitrogen mustard-based chemotherapeutic agents and prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop novel targeted cancer therapies.
• Bioconjugation Studies: Serves as a linker or payload in antibody-drug conjugate (ADC) research due to its reactive chloroethyl groups.
• Biochemical Probe Development: Employed to create molecular probes for studying alkylating agent mechanisms and DNA interaction.
• Academic Research: Utilized in university and institutional labs for investigating novel anti-cancer compounds and their modes of action.
• Process Development: Serves as a reference standard or starting material for scaling up synthetic routes in fine chemical production.

Basic Information

Product Name	o-Bis(2-Chloroethyl)Aminomethylphenylalanine Hydrochloride
CAS No.	3734-80-3
Molecular Formula	C14H21Cl3N2O2
Molecular Weight	355.69 g/mol
Synonyms	o-[Bis(2-chloroethyl)amino]methylphenylalanine hydrochloride; Phenylalanine, o-[bis(2-chloroethyl)amino]methyl-, hydrochloride; L-Phenylalanine, o-[bis(2-chloroethyl)amino]methyl-, hydrochloride (8CI); NSC 176319; o-(N,N-Bis(2-chloroethyl)aminomethyl)phenylalanine HCl; Ortho-bis(2-chloroethyl)aminomethylphenylalanine hydrochloride
EINECS	Contact for details

Quality Control

Our o-Bis(2-Chloroethyl)Aminomethylphenylalanine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.