Description

Palifosfamide CAS NO 31645-39-3 is a synthetic alkylating agent and a key intermediate in the development of targeted cancer therapeutics. This compound is valued for its role in the synthesis of prodrugs designed to improve the selectivity and reduce the systemic toxicity of chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced prodrug candidates, particularly those targeting hypoxic tumor environments.
• Oncology Research: Used in preclinical studies to investigate novel alkylating agent mechanisms and to develop next-generation chemotherapeutics with improved therapeutic indices.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the manufacturing process for experimental anticancer agents under clinical evaluation.
• Bioconjugation Studies: Employed in research focused on linking cytotoxic agents to antibodies, peptides, or polymers for targeted drug delivery systems.
• Chemical Biology Tool: Utilized as a probe to study DNA cross-linking and cellular response to alkylating damage in biochemical assays.

Basic Information

Product Name	Palifosfamide
CAS No.	31645-39-3
Molecular Formula	C5H12ClN2O2P
Molecular Weight	198.59 g/mol
Synonyms	Isophosphoramide mustard; IPM; N,N-Bis(2-chloroethyl)phosphorodiamidic acid; ZIO-201; (Bis(2-chloroethyl)amino)phosphonic acid diamide; GK-921; NSC-726189; TLK-286 (prodrug form)
EINECS	Contact for details

Quality Control

Our Palifosfamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable for pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.