Alkylating Antineoplastic Agents

Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

7-(4-Carboxybutanamido)Cephalosporin Mustard CAS NO 142478-50-0

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CAS No.:142478-50-0

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N,n-Dimethylaminoethylnitrosoethylurea CAS NO 142713-74-4

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CAS No.:142713-74-4

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Quinato(Cyclohexanediamine)Platinum(Ii) CAS NO 142928-30-1

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CAS No.:142928-30-1

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1-(4-(N,n-Bis-2-Chloroethylcarbamoyloxy)Phenyl)-1-(4-Hydroxyphenyl)-2-Phenylbut-1-Ene CAS NO 143134-33-2

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CAS No.:143134-33-2

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n-(3-((4-Aminobutyl)(3-Aminopropyl)Amino)Propyl)-4-(Bis(2-Chloroethyl) Amino)Benzenebutanamide CAS NO 143984-22-9

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CAS No.:143984-22-9

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1,3-Dipalmitoyl-2-(4'-(Bis(2''-Chloroethyl)Amino)Phenylalaninoyl)Glycerol CAS NO 144558-52-1

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CAS No.:144558-52-1

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Chloro(1,2-Diaminocyclohexane)(n-Methyliminodiacetato)Platinum(Iv) CAS NO 145482-83-3

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CAS No.:145482-83-3

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Eptaplatin CAS NO 146665-77-2

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CAS No.:146665-77-2

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