Description

n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Acetyl]-L-Methionine Ethyl Ester is a specialized synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its molecular architecture, featuring a nitrogen mustard moiety linked to a methionine derivative, makes it a critical building block for targeted therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel prodrugs and investigational compounds, particularly in oncology and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of investigational chemotherapeutic agents and prodrugs designed for targeted release.
• Anticancer Research: Used in R&D for developing novel nitrogen mustard-based compounds aimed at improving therapeutic index and reducing systemic toxicity.
• Prodrug Synthesis: Employed in constructing enzyme-activated or tumor-targeting prodrug systems, leveraging the methionine component for specific cleavage mechanisms.
• Bioconjugation Chemistry: Acts as a linker or payload in antibody-drug conjugate (ADC) research and other bioconjugation strategies.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties.
• Biochemical Research: Utilized in studies exploring amino acid transport and metabolism in cell models, given its methionine ester structure.

Basic Information

Product Name	n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Acetyl]-L-Methionine Ethyl Ester
CAS No.	3819-34-9
Molecular Formula	C20H30Cl2N2O3S
Molecular Weight	449.43 g/mol
Synonyms	L-Methionine, N-[[4-[bis(2-chloroethyl)amino]phenyl]acetyl]-, ethyl ester; Ethyl N-[[4-[bis(2-chloroethyl)amino]phenyl]acetyl]-L-methioninate; N-[[p-[Bis(2-chloroethyl)amino]phenyl]acetyl]-L-methionine ethyl ester; L-Methionine ethyl ester derivative of chlorambucil; Chlorambucil-methionine ethyl ester conjugate; 3819-34-9; Mustard-methionine prodrug intermediate
EINECS	Contact for details

Quality Control

Our n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Acetyl]-L-Methionine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.