Description

Cyanotemozolomide CAS NO 287964-59-4 is a specialized chemical derivative of temozolomide, a well-known alkylating agent used in oncology research. This compound is of significant interest for its potential role in the development of novel chemotherapeutic agents and as a key intermediate in advanced pharmaceutical synthesis. It is primarily utilized by research institutions and pharmaceutical development companies focused on oncology, neuro-oncology, and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of next-generation temozolomide analogs and prodrugs for cancer therapy research.
• Oncology Research: Used in biochemical and cellular studies to investigate mechanisms of DNA alkylation, apoptosis induction, and resistance pathways in glioblastoma and other solid tumors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency, bioavailability, and blood-brain barrier penetration of anticancer compounds.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical manufacturing and regulatory testing.
• Preclinical Development: Utilized in the formulation and testing of novel drug candidates in animal models for efficacy and pharmacokinetic profiling.

Basic Information

Product Name	Cyanotemozolomide
CAS No.	287964-59-4
Molecular Formula	C7H7N7O2
Molecular Weight	221.18 g/mol
Synonyms	4-Cyanotemozolomide; 8-Cyano-5-methyl-4-oxo-3,4,5,6-tetrahydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonitrile; 8-Cyano-5-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonitrile; Cyanotemozolomide (Cyanotemozolomide); TMZ-CN; Temozolomide cyanide derivative
EINECS	Contact for details

Quality Control

Our Cyanotemozolomide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.