Alkylating Antineoplastic Agents

Antineoplastics

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Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

4,6-Ethylidene Glucose Streptozotocin CAS NO 121230-21-5

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CAS No.:121230-21-5

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Content:99.90%

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n-(2-Hydroxyethyl)-P,p-Bisaziridinyl Thiophosphamide CAS NO 121258-29-5

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CAS No.:121258-29-5

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4-[Bis(2-Chloroethyl)Amino]-N,n-Dimethyl-Benzamide CAS NO 122567-50-4

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CAS No.:122567-50-4

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2-Amino-6(7)-(Bis(2-Chloroethyl)Amino)-1,2,3,4-Tetrahydro-2-Naphthalencarboxylic Acid CAS NO 123408-73-1

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CAS No.:123408-73-1

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n-Allyl-7-N,n-Bis(Beta-Chloroethyl)Amino-6,14-Endoethenotetrahydronororipavine CAS NO 123553-00-4

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CAS No.:123553-00-4

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6-n-Aziridinyl-3-Hydrox-7-Methyl-2,3-Dihydro-1H-Pyrrolo(1,2-A)Benzimidazole-5,8-Dione 3-Acetate CAS NO 123567-24-8

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CAS No.:123567-24-8

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9-Acridinamine, n-(5-(4-(Bis(2-Chloroethyl)Amino)Phenoxy)Pentyl)- CAS NO 125173-74-2

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CAS No.:125173-74-2

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n-[6-[4-[Bis(2-Chloroethyl)Amino]Phenyl]Hexyl]Acridin-9-Amine CAS NO 125173-75-3

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CAS No.:125173-75-3

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