Description

Treosulfan is a bifunctional alkylating agent belonging to the group of sulfonic acid esters, with the CAS registry number 299-75-2. This compound is of significant interest in the pharmaceutical and life sciences sectors due to its cytostatic properties and role as a key intermediate in advanced therapies. It is primarily utilized by research institutions and manufacturers engaged in the development of oncology treatments and conditioning regimens for hematopoietic stem cell transplantation. Its mechanism of action and high purity make it a critical component for preclinical and clinical-stage pharmaceutical applications.

Application

• Pharmaceutical Active Ingredient: Serves as a critical component in the formulation of chemotherapeutic agents and conditioning regimens, particularly prior to bone marrow or stem cell transplants.
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate alkylating agent mechanisms, cytotoxicity, and combination therapies for various cancers.
• Biochemical Synthesis: Acts as a versatile alkylating agent and building block in the synthesis of more complex molecules for medicinal chemistry and drug discovery programs.
• Cell Biology Studies: Employed in laboratory settings to study cell cycle arrest, DNA cross-linking, and apoptosis in experimental models.
• Process Development: Used by API (Active Pharmaceutical Ingredient) manufacturers for scaling up production processes under GMP (Good Manufacturing Practice) conditions.

Basic Information

Product Name	Treosulfan
CAS No.	299-75-2
Molecular Formula	C6H14O6S2
Molecular Weight	246.30 g/mol
Synonyms	L-Threitol-1,4-bismethanesulfonate; L-Treosulfan; (2S,3S)-1,2,3,4-Butanetetrol 1,4-Dimethanesulfonate; NSC 39069; Ovastat; Dihydroxybusulfan; Treosulfan; Treosulfanum
EINECS	206-081-6

Quality Control

Our Treosulfan is manufactured and tested to meet high-purity standards suitable for research and pharmaceutical applications. Each batch undergoes rigorous analytical testing, including HPLC for assay and purity, determination of related substances, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against established specifications. We support compliance with relevant pharmacopeial guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.