Description

Cloretazine CAS NO 173424-77-6 is a synthetic alkylating agent belonging to the sulfonylhydrazine class of compounds. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel therapeutic agents. The material is handled under controlled conditions to ensure its stability and integrity for critical applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential anticancer agents and other specialized active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in laboratory studies to investigate alkylation mechanisms and DNA interaction studies.
• Preclinical Development: Employed in the development and optimization of synthetic routes for new chemical entities (NCEs) in drug discovery pipelines.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Cloretazine
CAS No.	173424-77-6
Molecular Formula	C9H13Cl2N3O2S
Molecular Weight	298.19 g/mol
Synonyms	1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(2-chloroethyl)amino]carbonyl]hydrazine; Laromustine; VNP40101M; 101M; Cloretazine Hydrochloride (salt form); 1-(2-Chloroethyl)-2-[(2-chloroethyl)amino]carbonyl]-1,2-bis(methylsulfonyl)hydrazine; Onrigin
EINECS	Contact for details

Quality Control

Our Cloretazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results and confirming compliance with agreed specifications is provided with every shipment to ensure traceability and batch-to-batch consistency for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and degradation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.