Description

Picoplatin is a third-generation platinum-based antineoplastic agent designed to overcome resistance mechanisms associated with earlier platinum chemotherapeutics. Its unique structural modification, featuring a methyl-substituted pyridine ligand, enhances its stability and alters its DNA binding profile, making it a critical compound for advanced oncology research and development. This product is essential for pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on developing next-generation cancer treatments, particularly for platinum-resistant tumors.

Application

• Oncology Drug Development: As a key active pharmaceutical ingredient (API) in preclinical and clinical research for novel chemotherapeutic formulations.
• Mechanistic Studies: Used in biochemical and pharmacological research to study mechanisms of platinum resistance and DNA adduct formation.
• Combination Therapy Research: Investigation in synergistic treatment regimens with other anticancer agents or targeted therapies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Fundamental research in medicinal chemistry and molecular biology to understand structure-activity relationships of platinum complexes.

Basic Information

Product Name	Picoplatin
CAS No.	181630-15-9
Molecular Formula	C7H11Cl2N3Pt
Molecular Weight	424.17 g/mol
Synonyms	AMD-473; JM-473; ZD-0473; (SP-4-2)-Amminedichloro(2-methylpyridine)platinum; cis-Amminedichloro(2-methylpyridine)platinum(II); cis-[PtCl2(NH3)(2-picoline)]
EINECS	Contact for details

Quality Control

Our Picoplatin is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for pharmaceutical intermediates, and specifications can be aligned with customer requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.