Description

Trofosfamide CAS NO 1189884-36-3 is a synthetic alkylating agent belonging to the oxazaphosphorine class of nitrogen mustards. This compound is of significant interest in pharmaceutical research and development, primarily for its potential as an antineoplastic prodrug. It is a key intermediate and reference standard for researchers and manufacturers in the oncology and medicinal chemistry sectors, where precise chemical structure and high purity are critical for efficacy and safety studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex anticancer agents and prodrugs.
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate mechanisms of action, metabolism, and cytotoxicity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop novel chemotherapeutic agents with improved therapeutic indices.
• Biochemical Research: Utilized in studies exploring DNA alkylation, apoptosis induction, and cell cycle arrest in various cancer cell lines.
• Analytical Standard: Acts as a high-purity certified reference material (CRM) for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical labs.

Basic Information

Product Name	Trofosfamide
CAS No.	1189884-36-3
Molecular Formula	C9H19Cl2N3O3P
Molecular Weight	328.14 g/mol
Synonyms	N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide; Trofosfamid; A-4828; Z-4828; NSC-109723; 1,3,2-Oxazaphosphorinane, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide; Cyclophosphamide Impurity; Oxazaphosphorine derivative
EINECS	Contact for details

Quality Control

Every batch of Trofosfamide is manufactured and tested under strict quality management systems. We provide material that meets high-purity standards suitable for research and development. Comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and impurity profiling, is performed. A Certificate of Analysis (COA) detailing all test results and specifications is supplied with each shipment to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.