Description

Bendamustine D-Mannitol Ester is a chemically modified prodrug of the established alkylating agent bendamustine, designed for targeted therapeutic delivery. This innovative esterification with D-mannitol aims to enhance solubility, stability, and potentially modulate the pharmacokinetic profile of the active pharmaceutical ingredient. It is a critical intermediate for pharmaceutical R&D, particularly in the development of next-generation oncology therapeutics and advanced drug delivery systems. Researchers and manufacturers in the pharmaceutical and biotech sectors require this high-purity compound for preclinical studies and process development.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and production of novel chemotherapeutic agents.
• Oncology Drug Development: Used in preclinical and clinical research for developing improved bendamustine-based therapies with potentially enhanced efficacy or reduced side effects.
• Prodrug Synthesis: Acts as a building block for creating targeted prodrugs designed for specific activation within tumor microenvironments.
• Drug Delivery System Research: Incorporated into studies focusing on conjugate formulations, such as antibody-drug conjugates (ADCs) or nanoparticle carriers.
• Chemical Biology Studies: Utilized as a tool compound to investigate mechanisms of action and resistance pathways related to alkylating agents.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Bendamustine D-Mannitol Ester
CAS No.	1869075-89-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bendamustine D-Mannitol Ester; Bendamustine Mannitol Ester; 4-[5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoic acid mannitol ester; Mannitol bendamustine ester; Bendamustine prodrug with mannitol
EINECS	Contact for details

Quality Control

Our Bendamustine D-Mannitol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, confirming compliance with agreed specifications. Our commitment to cGMP principles ensures consistent quality and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C) or as specified on the certificate of analysis. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities <2.0%
Single Maximum Unknown Impurity	<0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.