Description

Ortho-Chlorambucil CAS NO 178481-89-5 is a specialized chlorinated derivative of the nitrogen mustard alkylating agent chlorambucil. This compound is of significant interest in pharmaceutical research and development, particularly for the synthesis of novel therapeutic agents and as a key intermediate in medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted cancer therapies and other specialized pharmaceutical applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel alkylating agents and targeted cancer therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new compounds with modified pharmacological profiles.
• Biochemical Research: Employed as a tool compound in studies investigating DNA alkylation mechanisms and cellular response pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Utilized in the early-stage development and optimization of new chemical entities (NCEs) for oncology.

Basic Information

Product Name	Ortho-Chlorambucil
CAS No.	178481-89-5
Molecular Formula	C14H19Cl2NO2
Molecular Weight	304.21 g/mol
Synonyms	2-[4-[Bis(2-chloroethyl)amino]phenyl]butanoic acid; 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid (ortho-isomer); o-Chlorambucil; Ortho-Chlorambucil; Chlorambucil impurity; Chlorambucil related compound; NSC 3088 (related isomer); Leukeran isomer
EINECS	Contact for details

Quality Control

Our Ortho-Chlorambucil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.